Organophosphate induced Delayed Myeloneuropathy
Abstract
Organophosphorus compounds are common
insecticidal agents used in India.
Their use as a suicidal agent is also well
known often leading to massive organophosphorus-
compound intoxication. Although
uncommon, delayed neurotoxicity
has been consistently reported in literature
probably related to the inhibition of
neurotoxic esterase. This mechanism is
implicated not only in damaging peripheral
nervous sytem but also in causing
central processes leading to Myelopathy.
We describe a patient who had a classic
acute cholinergic crisis after exposure to
organophosphates, with the subsequent
development of organophosphateinduced
delayed neuropathy. Magnetic
resonance imaging (MRI) showed diffuse
spinal cord atrophy that persisted long
after the cholinergic effects had subsided.
Full Text:
PDFReferences
Cherniack MG. Organophosphorus
esters and polyneuropathy.
Ann. Intern. Med. 1986 Feb;104
(2):264–6.
Abou-Donia MB, Lapadula DM.
Mechanisms of Organophosphorus
Ester-Induced Delayed Neurotoxicity:
Type I and Type II. Annu. Rev.
Pharmacol. Toxicol. 1990;30
(1):405–40.
Tsai M-H, Tsai N-W, Chen S-F,
Tsai H-H, Lu C-H, Huang C-R, et
al. Organophosphate intoxicationrelated
coital-like involuntary
movements: report of A case. Acta
Neurol. Taiwanica. 2006 Mar;15
(1):34–7.
Eyer P. Neuropsychopathological
changes by organophosphorus
compounds--a review. Hum. Exp.
Toxicol. 1995 Nov;14(11):857–64.
Duffy FH, Burchfiel JL, Bartels
PH, Gaon M, Sim VM. Long-term
effects of an organophosphate
upon the human electroencephalogram.
Toxicol. Appl. Pharmacol.
Jan;47(1):161–76.
Lotti M, Becker CE, Aminoff MJ. Organophosphate
polyneuropathy: pathogenesis
and prevention. Neurology. 1984
May;34(5):658–62.
Thivakaran T, Gamage R, Gunarathne
KS, Gooneratne IK. Chlorpyrifos-induced
Delayed Myelopathy and Pure Motor
Neuropathy. The Neurologist. 2012
Jul;18(4):226–8.
Chuang C-C, Lin T-S, Tsai M-C. Delayed
Neuropathy and Myelopathy after
Organophosphate Intoxication. N. Engl.
J. Med. 2002;347(14):1119–21.
Johnson MK. The delayed neurotoxic
effect of some organophosphorus compounds.
Identification of the phosphorylation
site as an esterase. Biochem. J.
Oct;114(4):711–7.
Gadoth N, Fisher A. Late onset of
neuromuscular block in organophosphorus
poisoning. Ann. Intern. Med. 1978
May;88(5):654–5.
Dickoff DJ, Gerber O, Turovsky Z. Delayed
neurotoxicity after ingestion of carbamate
pesticide. Neurology. 1987 Jul;37
(7):1229–31.
`12 Yang PY, Tsao TC, Lin JL, Lyu RK,
Chiang PC. Carbofuran-induced delayed
neuropathy. J. Toxicol. Clin. Toxicol.
;38(1):43–6.
Funk KA, Henderson JD, Liu CH, Higgins
RJ, Wilson BW. Neuropathology of
organophosphate-induced delayed neuropathy
(OPIDN) in young chicks. Arch.
Toxicol. 1994;68(5):308–16.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An initiative of The Tamil Nadu Dr M.G.R. Medical University