Collapsing Glomerulopathy in Renal Transplant Recipients - Two Case Reports
Abstract
Collapsing focal segmental glomerulosclerosis
or Collapsing glomerulopathy
(CG) is a distinct clinicopathological variant
of focal segmental glomerulosclerosis
characterized pathologically by the
segmental or global collapse of the
glomerular capillaries, marked hypertrophy
and hyperplasia of visceral epithelial
cells , and severe tubulointerstitial disease
and clinically characterised by
nephrotic proteinuria and rapidly progressive
renal failure. This has been reported
in transplanted kidneys either as recurrent
or de novo disease, resulting in allograft
failure. We report two renal transplant
recipients who developed graft dysfunction,
nephrotic proteinuria and biopsy
proven CG. Work-up for secondary
causes was negative and renal function
declined rapidly with the need for dialysis
in both the patients.
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