AN INTERESTING CASE OF JAUNDICE
Abstract
Overlap syndrome is used to describe
variant forms of autoimmune hepatitis
(AIH) which present with characteristics
of AIH and primary biliary cirrhosis (PBC)
or primary sclerosing cholangitis (PSC).
Patients with overlap syndromes present
with both hepatitic and cholestatic serum
liver tests and have histological features
of AIH and PBC or PSC. AIH-PBC is the
most common form of overlap syndrome,
affecting almost 10 of adults with AIH or
PBC. Overlap syndromes show a progressive
course without treatment, and
therapy is empiric. Ursodeoxycholic acid
is usuallycombined with immunosuppressive
therapy but end-stage disease requires
liver transplantation. We report a
case of AIH-PBC overlap syndrome presenting
with jaundice.
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