Cover Image

AN INTERESTING CASE OF JAUNDICE

ARUN THANGARAJ

Abstract


Overlap syndrome is used to describe
variant forms of autoimmune hepatitis
(AIH) which present with characteristics
of AIH and primary biliary cirrhosis (PBC)
or primary sclerosing cholangitis (PSC).
Patients with overlap syndromes present
with both hepatitic and cholestatic serum
liver tests and have histological features
of AIH and PBC or PSC. AIH-PBC is the
most common form of overlap syndrome,
affecting almost 10 of adults with AIH or
PBC. Overlap syndromes show a progressive
course without treatment, and
therapy is empiric. Ursodeoxycholic acid
is usuallycombined with immunosuppressive
therapy but end-stage disease requires
liver transplantation. We report a
case of AIH-PBC overlap syndrome presenting
with jaundice.


Full Text:

PDF

References


Duclos-Vallee JC, Hadengue A,

Ganne-Carrie N, Robin E, Degott C, Erlinger

S. Primary biliary cirrhosisautoimmune

hepatitis overlap syndrome.

Corticoresistance and effective treatment

by cyclosporine A. Dig Dis Sci

;40:1069-1073.

Chazouilleres O, Wendum D, Serfaty L,

Montembault S, Rosmorduc O, Poupon

R. Primary biliary cirrhosis autoimmune

hepatitis overlap syndrome: clinical features

and response to therapy. Hepatology

;28:296-301.

Gerken G, Dienes HP. Characterization

of the overlap syndrome of primary biliary

cirrhosis (PBC) and autoimmune hepatitis:

evidence for it being a hepatitic form

of PBC in genetically susceptible individuals.

Hepatology 1999;29:1078-1084.

Heathcote EJ. Overlap syndromes. In:

Bircher JBJ, McIntyre N, Rizzeto M,

Rodès J, eds. Oxford Textbook of Clinical

Hepatology ,Vol. 2. Oxford: Oxford University

Press, 1999;1135–40.


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An initiative of The Tamil Nadu Dr M.G.R. Medical University