Recurrent Hypokalemic Paralysis - An Interesting Cause
Abstract
Abstract : Recurrent hypokalemic paralysis is caused y either channelopathies or by conditions associated with recurrent or persistent renal or non renal losses of potassium. Distal renal tubular acidosis (dRTA) is one of the causes of renal potassium loss leading to hyokalemia. One of the important presentations of dRTA is recurrent hypokalemic weakness, which can be life threatening.a We would like to present one such case of recurrent hypokalemic paralysis with respiratory weakness secondary to dRTA. Type 1 or dRTA involves impaired distal acidification of urine. dRTA often presents as renal stone disease with nephrocalcinosis in adults, rickets and growth retardation in children with ultimate short stature in adulthood. Our case is a 19-year-old male who had features of dRTA like recurrent hypokalemic paralysis, metabolic acidosis, stunted growth, rickets and nephrocalcinosis.
Keyword :Recurrent hypokalemic paralysis, Metabolic acidosis, Abnormal urine pH, Short stature,Rickets, Nephrocalcinosis, Distal Renal Tubular Acidosis.
Full Text:
PDFReferences
Dan L Longo, Dennis L Kasper, J Larry Jameson, Anthony S Fauci, Stephen L Hauser, Joseph Loscalzo, Harrison’s Principals of Internal Medicine
,18th edition, volume 2, chapter 284.
Koul PA, Salcem SM, chronic active hepatitis with renal tubular acidosis presenting as hypokalemic paralysis with respiratory failure, Ada Paediatr
;31:662–665.
Lightwood R. Calcium infarction of kidney in infants. Arch Dis Child 1935;10:205–210.
Butler AM, Wilson JL, Farber S. Dehydration and acidosis with calcification of renal tubules. J Pediatr 1936;8:489–499.
Baines GH, Barclay JA, Cooke WT. Nephrocalcinosis
associated with hyperchloremia and low plasma bicarbonate. Q J Med 1945;14:113–122.
Horacio J. Adrogu, Nicolaos E. Madias, Renal tubular acidosis, Davison, Alex M.; Cameron, J. Stewart, Grunfeld, Jean-Pierre, Ponticelli, Claudio,
Ritz, Eberhard, Winearls, Christopher G., Ypersele, Charles van (Eds.), Oxford Textbook of Clinical Nephrology, 2005, 3rd edition, chapter 5.4.
Basak RC, Sharkawi KM, Rahman MM, Swar MM. Distal renal tubular acidosis, hypokalemic paralysis, nephrocalcinosis, primary hypothyroidism,
growth retardation, osteomalacia and osteoporosis leading to pathological fracture: a case report. Oman Med J 2011 Jul;26(4):271–274.
Seldin and Gieisch. Clinical syndromes of metabolic acidosis. The Kidney, 4th edition, volume 2.
DuBose TD, Jr. Disorders of acid base balance. Barry M. Brenner, Brenner and Rector’s The Kidney, Philadelphia: WB Saunders, 8th edition, volume
, chapter 14.
DuBose TD, McDonald GA, Renal tubular acidosis. DuBose TD, Hamm LL (Eds), Acid-Base and Electrolyte Disorders: A Companion to Brenner and
Rector's The Kidney, Philadelphia: WB Saunders; 2002:189–206.
Troels Ring. Renal tubular acidosis. Ronco, Bellomo, Kellum (Eds.). Critical Care Nephrology 2nd edition.
DuBose TD. Autosomal dominant distal renal tubular acidosis and the AE1 gene. Am J Kid Dis 1999;33: 1190–1197.
Chaabani H, Hadj-Khlil A, Ben-Dhia N, Braham H. The primary hereditary form of distal renal tubular acidosis: clinical and genetic studies in 60-
member kindred. Clin Genet 1994;45:194–199.
Morris, Jr, RC, Sebastian A: Alkali therapy in renal tubular acidosis: Who needs it?. J Am Soc Nephrol 2002; 13:2186–2188.
Wrong O, Henderson JE, Kaye M: Distal renal tubular acidosis: Alkali heals osteomalacia and increases net production of 1,25-dihydroxyvitamin D. Nephron Physiol 2005; 101:72–76.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An initiative of The Tamil Nadu Dr M.G.R. Medical University