THYMIC CARCINOID CAUSING PARANEOPLASTIC CUSHING'S SYNDROME - A RARE CASE REPORT
Abstract
Abstract : Cushing's syndrome reflects a constellation of clinical features from chronic exposure to excess glucocorticoids of any etiology. This disorder can be ACTH dependent (pituitary corticotrope adenoma, ectopic secretion of ACTH) or ACTH independent (adrenocortical adenoma, adrenocortical carcinoma, nodular adrenal hyperplasia) as well as iatrogenic. The term Cushing's disease reflects to Cushing syndrome caused by pituitary adenoma. We present here a case of ectopic ACTH producing thymic carcinoid in a 17 year old male patient who was diagnosed and treated in our hospital. He presented to us with acute onset Cushing's syndrome, on evaluation he was found to have an anterior mediastinal mass which was excised. On histopathological examination and immunohistochemistry showed a thymic carcinoid. Patients symptoms and features of Cushings syndrome reduced after excision of the tumour.
Keyword :ACTH,THYMIC CARCINOID, CUSHING'S SYNDROME
Abstract : Cushing's syndrome reflects a constellation of clinical features from chronic exposure to excess glucocorticoids of any etiology. This disorder can be ACTH dependent (pituitary corticotrope adenoma, ectopic secretion of ACTH) or ACTH independent (adrenocortical adenoma, adrenocortical carcinoma, nodular adrenal hyperplasia) as well as iatrogenic. The term Cushing's disease reflects to Cushing syndrome caused by pituitary adenoma. We present here a case of ectopic ACTH producing thymic carcinoid in a 17 year old male patient who was diagnosed and treated in our hospital. He presented to us with acute onset Cushing's syndrome, on evaluation he was found to have an anterior mediastinal mass which was excised. On histopathological examination and immunohistochemistry showed a thymic carcinoid. Patients symptoms and features of Cushings syndrome reduced after excision of the tumour.
Keyword :ACTH,THYMIC CARCINOID, CUSHING'S SYNDROME
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