THE PREVALENCE OF SECRETOR STATUS AND CO-EXPRESSION OF LEWIS ANTIGEN IN VOLUNTARY BLOOD DONORS
Abstract
Abstract : Blood group substances are present in soluble form
in a majority of individuals in secretion such as saliva and body
fluids. Secretor status refers to the presence (SeSe and Sese)
or absence (sese) of secretor gene which secrete ABH soluble
substances. People having the secretor gene are called
Secretors and those who do not have are called
non-secretors. The ability to secrete ABH antigens is
genetically inherited, approximately 80 percent are secretors
and 20 percent are non-secretors. This percentage of secretor
and non- secretor varies according to the race and ethnicity.
The Lewis (Le) gene resides on Chromosome 19 and is
distantly linked to H and Se loci. Lewis antigens are not
intrinsic to the RBC but are synthesized in intestinal epithelial
cells. This study was conducted in order to find out the
prevalence of secretor status and co-expression of Lewis
antigens in the voluntary blood donors. The method used to
determine the secretor status was hemagglutination inhibition
method. 5 ml of saliva was collected from a total number of 60
donors who participated in this study. 45 of them were found to
be secretors and 15 of them were non-secretors .Their blood
was used to detect the type of Lewis (Le) antigen since the
type of Lewis antigen correlated with the secretor status of the
individual, in which 39 out of 45 secretors were found to be
Lewis b positive, 12 out of 15 non-secretors were found to be
Lewis a positive. The remaining 6 secretors and 3
non-secretors were Lewis 'a' and 'b' negative.
Keyword :Secretors, Non-secretors, Lewis antigen,
Hemagglutination inhibition
Full Text:
PDFReferences
Denise M. Harmening. Modern blood banking and Transfusion
practices. Fifth Edition 2008:133
Christopher D. Hillyer, Leslie Silberstein, Paul M.Ness, Kenneth
C. Anderson, John D. Roback. Blood banking and transfusion
Medicine. Second Edition 2007:73-75
Toby L.Simon, Walter Dzik, Edward L.Snyder, Christopher P.
Stowell, Ronald G. Strauss. Rossi’s Principles of Transfusion
Medicine 2002. Third Edition: 97
Geoff Daniels. Human Blood Groups. Second Edition 2002 :29
P.H Andresen Relations between the ABO, Secretor/Non-
Secretor and Lewis Systems with particular reference to the
Lewis system. Bisperbjerg Hospital, Copenhagen 1961:
-412
S Akhter, GM Kibria, NR Akhter, MM Habibulah, SMK
Islam, M Zakariah . ABO and Lewis blood grouping with
ABH Secretor and Non-secretor status: A cross sectional
study in Dhaka. Faridpur Med.Coll.J 2011;6(1):38-40
Sara Linden, Jafar Mahdavi, Cristina Semino-Mora, Cara
Olsen, Ingemar Carlstedt, Thomas Boren .Role of ABO
Secretor status in mucosal innate immunity and H.pylori
infection. PLoS Pathogens 2008; 4( 1) : 6-12
F.E Camps,Barbara E.Dodd, P.J.Lincoln. Frequencies os
Secretors and Non-secretors of ABH Group Substances
among 1000 Alcoholic patients. British Medical Journal
; 4: 457-459.
Dayaprasad g. kulkarni and Venkatesh D. Non-Secretor
Status. A predisposing factor for vaginal candidiasis. Indian
J Physiol Pharmacol 2003 ; 48(20):225-229
Else Marie Vestergaard, Hans Ole Hein, Harald meyer,
Niels Grunnet, Jan Jorgensen, Hans wolf, Torben.
Reference Values and Biological Variation for Tumor Marker
CA 19-9 in Serum for Different Lewis and Secretor
Genotypes and Evaluation of Secretor and Lewis
Genotyping in a Caucasian Population. Clinical Chemistry
; 45 : 54-61.
John.D.Roback, Brenda J. Grossman, Teresa Harris,
Christopher D. Hillyer. AABB Technical Manual 17th
Edition:883-885
Luiz Carlos de Maltos, Juliana Rodrigues, Fabio
Eduardo, Rita de Cassia, Milton Artur,Harolda Wilson Moreria)
ABO, Lewis, Secretor and Non-secretor phenotypes in
patients infected or uninfected by the H.pylori bacillus. Sao
Paulo Med J/Rev Paul Med 2002 ;20(2):55-58
Tereza Cristina Oliveira Corvelo, D.C.F Aguiar,
F.E.S.Sagica The expression of ABH and Lewis antigens in
Brazilian semi isolates Black communities. Genetics and
Molecular Biology 2002; 25(3): 259-263
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An initiative of The Tamil Nadu Dr M.G.R. Medical University