Comparision of preemptive Gabapentin and Pregabalin for postoperative pain after surgery under spinal anesthesia

Abstract

Abstract :
This study was designed to compare the efficacy of
preemptive Gabapentin and Pregabalin with respect to
preoperative anxiety score , intraoperative sedation ,
hemodynamic stability , duration of postoperative analgesia
and side effects METHODS This prospective randomized
study was conducted in sixty patients scheduled for inguinal
surgeries under spinal anaesthesia. Sixty patients in ASA I
and II with age ranging from 30-60 years , with no history of
drug allergy or any contraindication to spinal anaesthesia
were included . patients were randomly allotted into two
groups of 30 each Group G(Gabapentin 800mg) and Group P
(Pregabalin 300mg). The study drugs , Gabapentin and
Pregabalin were given orally one hour before the planned
spinal procedure. Preoperative anxiety score was assessed
by visual analogue scale . The intraoperative sedation was
assessed by Ramsay sedation score and postoperative pain
was assessed by visual analogue scale. The duration of
postoperative analgesia was calculated from the time of
spinal anaesthesia to the first dose of rescue analgesia.
RESULTS
There was significant reduction in anxiety (P0.0001) in both
the groups in the preoperative period after institution of the
drug and also the reduction is significant between two groups
(P0.0001). Mean blood pressure , Heart rate , SPO2 and
Respiratory rate were similar (P0.05) in two groups. Sedation
in group G was 1.030.18 whereas in group P was 2.370.49
( significant P0.0001). Total postoperative analgesia in group
G was 232.76.3min whereas in group P was 459.112.1min
( significant P0.0001). No side effects were noted.
CONCLUSION
Gabapentin and Pregabalin , both have been effective in
prolongation of post-spinal analgesia , pregabalin more than
Gabapentin .
Keyword :Gabapentin , Pregabalin , spinal analgesia ,
preemptive analgesia