Therapeutic efficacy of different antibiotics against pathogenic non-fermenters for appropriate selection of drugs

Priyanka Sabu,Yamuna Devi Bakthavatchala .

Abstract


Pathogenic non-fermenters are being increasingly         isolated from clinical specimens and are usually multidrug               resistant, thus limiting the treatment possibilities. The aim of this study was to determine the Efficacy Ratio (ER) of different            antibiotics against Pseudomonas aeruginosa and Acinetobacter baumannii-calcoaceticus(ABC) complex for appropriate drug selection.A total of 122 isolates which consisted of 78 P.aeruginosa and 44 ABC complex isolates obtained from blood cultures of patients were included in the study. All isolates were tested for minimum inhibitory concentration (MIC) by VITEK 2. Then the ER was calculated for each isolate using the formula, ER = Susceptible breakpoint MIC ÷ MIC of isolate. The ER < 1 when drugs were resistant and ≥ 1 when susceptible. Higher the ER value, more effective the antibiotic will be.


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