Syndrome of Irreversible Lithium – Effectuated Neurotoxicity (Silent Syndrome)

Renganathan S, Alexander Gnanadurai W J .

Abstract


SILENT syndrome (Syndrome of Irreversible    Lithium-Effectuated Neurotoxicity) is a rare permanent   neurological sequelae of lithium toxicity that develops in           patients without any previous history of neurological  impairment. Most  classically it causes a fine, 8–12 Hz  postural tremor considered to be an “enhanced” physiological tremor. Cognitive impairment, ataxia, dyskinesia and               incoordination may also occur. Despite the availability of newer drugs, lithium remains the most effective treatment for bipolar disorder. But treatmentwith lithium is complicated by its narrow therapeutic index and its effects on renal function, both of which increasesthe risk of toxicity. Hence, careful attention to its administration is needed. Chronic toxic effects of lithium result when the intake exceeds elimination.

 

Keywords: silent syndrome, lithium toxicity,bipolar disorder.

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References


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