Evaluation of Fosfomycin Susceptibility among Multidrugresistant Gram Negative Urinary Isolates in a Tertiary Care Hospital
Abstract
Introduction: Urinary tract infections are one of the commonest types of bacterial infections.Multidrug resistance in Gram negative bacteria is an ever increasing problem worldwide. Of particular concern, the spread of Extended Spectrum b Lactamases and Carbapenamases is increasing worldwide.Fosfomycin, an old broad spectrum antibiotic is found to be bactericidal against multidrug resistant uropathogens.
Aim of the study: This study aimed to evaluate the in vitro susceptibility of Fosfomycin against multi drug resistant gram negative urinary isolates
Materials and Methods: This is a prospective study conducted between April-Sep 2017,in which 100 non -repetitive multidrug resistant gram negative urinary isolates were collected and their anti microbial susceptibility patterns to Fosfomycin were determined as per CLSI and EUCAST guidelines
Results: E.coli (97%)and Klebsiella pneumonia(88%),Klebsiella oxytoca(80%) were found to be sensitive to Fosfomycin. Among non Enterobacteriaceae ,Pseudomonas spp were found to be 100% sensitive and Acinetobacter spp (17%) was found to be least sensitive.
Conclusion: Fosfomycin is active in vitro against considerable percentage of multidrug resistant urinary isolates. Consequently Fosfomycin appears to be the best treatment option for the urinary tract infections.
Keywords: Fosfomycin, ESBLs, Carbapenemases, UTI, Gram negative infections
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