Cover Image

A Study of Executive Functioning in Type 2 Diabetes Mellitus Patients in Relation with the Duration of Diabetes

Sowmiya K and Vijayalakshmi R .

Abstract


Background: Type 2 diabetes mellitus increases the incidence of cognitive impairment by two to three fold when compared to non-diabetics. This causes impairment in the Activities of Daily Living (ADL) in the patients which in turn leads to immeasureable caregiver burden and increase in healthcare expenditure. Effective functioning in ADL depends upon the intact executive functions controlled by the Frontal lobe. Objective: To measure the executive functioning in type 2 diabetes patients using Frontal Assessment Battery (FAB). Materials and Methods: Fifty six Type 2 diabetes mellitus patients in the age group of 30-50 yrs in both genders were screened for dementia using Mini Mental Scale Examination (MMSE). Then their executive functions were assessed using FAB under six domains- conceptualization, mental flexibility, programming, sensitivity to interference, inhibitory control and environmental autonomy. Results: The total scores of MMSE, FAB and the individual scores of six domains of

FAB were correlated with duration of diabetes using Pearson rank correlation and a statistically significant linear correlation was obtained in the negative direction for all the variables. Conclusion: Type 2 diabetes is associated with poor executive functioning and the same deteriorates as the duration of disease increases.


Full Text:

PDF

References


Kaplan &Sadock’s Comprehensive Textbook of Psychiatry, 9th edition.

Tranel D, Anderson SW, Benton A: Development of the concept of “executive function” and its relationship to the frontal lobes, in Handbook of Neuropsychology, vol 9, edited by Boller F, Grafman J. Amsterdam, Elsevier Science, 1994, pp 125–148

Marsden CD: The mysterious motor function of the basal ganglia: the Robert Wartenberg lecture. Neurology 1982; 32:514–539

Alexander GE, DeLong MR, Strick P: Parallel organization of functionally segregated circuits linking basal ganglia and cortex.Annu Rev Neurosci 1986; 9:357–381

Harada CN, Natelson Love MC, Triebel K. Normal Cognitive Aging. Clinics in geriatric medicine. 2013;29 (4):737-752. doi:10.1016/j.cger.2013.07.002.

Rinn WE: Mental decline in normal aging: a review. J Geriatr Psychiatry Neurol 1988; 1:144–158

Boone KB, Miller BL, Lesser IM, et al: Performance on frontal lobe tests in healthy older individuals. Dev Neuropsychol 1990;6:215–223.

Thabit H1, KyawTun T, McDermott J, Sreenan S. Executive function and diabetes mellitus--a stone left unturned? Curr Diabetes Rev. 2012 Mar;8(2):109-15.

Lishman’sOrganic Psychiatry, A Textbook of Neuropsychiatry, 4th edition.

Van den Berg E, Reijmer YD, de Bresser J, Kessels RP, Kappelle LJ, Biessels GJ. A 4 year followup study of cognitive functioning in patients with type 2 diabetes mellitus. Diabetologia. 2010;53:58–65. [PubMed: 19882137]

Christman AL, Matsushita K, Gottesman RF, et al. Glycatedhaemoglobin and cognitive decline: the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia. 2011;54(7):1645-1652. doi:10.1007/ s00125-011-2095-7.

Zhao Q, Roberts RO, Ding D, et al. Diabetes is Associated with Worse Executive Function in both Eastern and Western populations: Shanghai Aging Study and Mayo Clinic Study of Aging. Journal of Alzheimer’s disease : JAD. 2015;47(1):167-176. doi:10.3233/JAD-150073.

Knopman D, Boland LL, Mosley T, et al. Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology. 2001; 56:42–48. [PubMed: 11148234]

Brownlee M 2005 The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54:1615–1625

Biessels GJ, van der Heide LP, Kamal A, Bleys RL, Gispen WH 2002 Ageing and diabetes: implications for brain function. Eur J Pharmacol 441:1–14

Kodl CT, Seaquist ER. Cognitive Dysfunction and Diabetes Mellitus. Endocrine Reviews. 2008;29(4):494-511. doi:10.1210/er.2007-0034.


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An initiative of The Tamil Nadu Dr M.G.R. Medical University