Serum Gamma-Glutamyl Transferase in Coronary Artery Disease Patients
Abstract
Abstract
Gamma-glutamyl transferase is an enzyme located in the external surface of cellular membrane. It is helpful in replenishing intracellular antioxidant glutathione by cleaving extracellular glutathione contributing to antioxidant inadequacy.Increased levels of GGT has been found to be associated with coronary heart disease,stroke, systemic hypertension,cardiac arrhythmias and heart failure. Studies show the presence of catalytic GGT in the atherosclerotic plaques. This study was carried out to explore the relationship between GGT and coronary artery disease(CAD). Twenty five angiographically proven CAD patients attending cardiology OPD for follow up and twenty five age and sex matched healthy controls were studied. GGT and lipid profile were analysed.
Results
Serum GGT was found to be higher in cases than in control subjects. GGT levels correlated positively with total cholesterol and LDL cholesterol. There was also a positive correlation between GGT levels and coronary complexity.
Conclusion
GGT, an indicator of antioxidant inadequacy can be used as a predictive biomarker for coronary artery disease.
Key Words:Coronary Artery Disease(CAD),Gamma-glutamy ltransferase(GGT), glutathione.
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