Quantitative Analysis of Commercial Preparations of Isoniazid
Abstract
Aim: To quantitatively estimate the strengths of isoniazid in commercial preparations using spectrophotometry. Methods: 49 isoniazid tablets of strength of 300 mg were bought from a local pharmacy. Ultraviolet spectrophotometer from the department of
Pharmacology was utilised for estimation of actual tablet strength using the method described by Enoch Florence Oga.(1) Results: A total of 49 commercially available Isoniazid tablets were estimated in duplicates. The mean and SD for the 49 tablets was estimated as 295.2±12.2 mg. Conclusion: The strength of all Isoniazid tablets from commercial preparations were within normal range of 90 to 110% as prescribed by WHO.
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