Primary adenosquamous carcinoma of the Esophagus : A rare case report
Abstract
Primary adenosquamous carcinoma of the esophagus is a rare malignancy. It is difficult to confirm histologically by endoscopic biopsy. It can arise de novo or from a pre existing Barrett’s esophagus. The modality of treatment is surgical resection. It has an aggressive biological behavior when compared to conventional squamous cell carcinoma of the esophagus. We reported a case of adenosquamous carcinoma of the esophagus in a 44 year old male who initially underwent endoscopic biopsy which showed features of poorly differentiated carcinoma. In the resection specimen, both squamous and adeno carcinoma components were found and confirmed by immunohistochemical expression. A thorough sampling of the resected specimen is essential in cases of poorly differentiated carcinomas because adenosquamous carcinoma of the esophagus has an aggressive clinical behavior. This case is being published because of its rarity and the diagnostic challenges faced in endoscopic biopsy interpretation.
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