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Evaluation of Analgesic Activity of Benazepril in Albino Rats

Meenambal S, Raadhika K, Malathi M, Par .

Abstract


Aim and Objective: To evaluate the analgesic activity of Benazepril in adult male albino rats in comparison with          Aspirin.

 Materials and Methods: Twenty four inbred male albino -* weighing about 150-200 gms were selected from central          animal house, Madurai Medical college, Madurai. They were divided into four groups, with six rats in each. Group I served as control received normal feed and water. Group II served as standard received T.aspirin – 100 mg/kg (oral). Group III was test 1 group and it received

 T.Benazepril - 5mg/kg (oral). Group IV was test 2 group and it received T.Benazepril - 10mg/kg (oral). The analgesic effect of benazepril was evaluated using Eddy’s hot plate method and tail-flick method and compared with the standard analgesic aspirin. The values obtained are expressed as mean ± SEM. Statistical analysis of differences between groups was carried out using one-way analysis of variance (ANOVA). Probability (P) value of <0.05 was taken as the level of statistical               significance

 Results: Benazepril showed statistically significant analgesic activity in comparison with control group and standard group  (P < 0.05).

 Conclusion: In the present study, Benazepril has showed promising results when compared to the control group. It may be a lead compound for identifying newer adjuvant analgesic agents.

 Keywords : Benazepril, aspirin, analgesic, hot plate, tail flick

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