Diclofenac - Serratiopeptidase Combination Induced Exfoliative Dermatitis: A Case Report
Abstract
Exfoliative dermatitis (ED) is an inflammatory
dermatosis involving more than 90% of body surface
area. It is caused by exposure to drugs and cause
significant morbidity and mortality. Diclofenac and
Serratiopeptidase are documented as a cause in inducing
Exfoliative Dermatitis. A careful literature search
revealed that only a few reports of diclofenac induced
and one case of serratiopeptidase associated case
report of Stevens-Johnson syndrome (SJS) or toxic
epidermal necrolysis (TEN) have been published till date.
However, to our knowledge, no case report of
diclofenac-serratiopeptidase combination induced ED have
been published till date from southern part of Tamilnadu.
Hence we describe the first case of a 65 year old male who
developed progressive rashes and blisters over the limb
extremities following intake of diclofenac and
serratiopeptidase combination.
A provisional diagnosis of Exfoliative dermatitis was
made by the treating physician. After administration of
Tablet prednisolone 10 mg twice daily, tablet paracetamol
500 mg thrice daily and topical application of
betamethasone cream with glycerine lotion on the affected
area thrice daily, patient recovered and was discharged.
Causality analysis on the World Health Organization scale
indicates a probable association with offending drugs.
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