Total Body Irradiation as a Part of Conditioning Regimen in Bone Marrow Transplantation – A Single Centre Experience from India
Abstract
Background: Total body irradiation (TBI) is an integral part of myeloablative conditioning in leukemia transplants. Feasibility and technical expertise is required to perform TBI. The data on TBI is scarce as very few centers in India are equipped to perform TBI. Our study aims to look into the profile of patients who received TBI as part of BMT conditioning regimen.
Methods: Data were collected retrospectively from case records of patients who had received TBI as conditioning regimen from January 2011 to December 2016. Profile of patients included baseline characteristics, underlying diagnosis, conditioning regimen, TBI dose and complications.
Results: Twenty-four patients (median age:39 years, 66% males) were included. Median follow up was 11.5 months after the transplantation. Most common indication was relapsed ALL in CR2 (N=9, 38%). Most common conditioning regimen used was Cy- TBI (N=20, 84%). Most frequently used dose of TBI used was 12 Gy in 6 fractions (N=21, 88%). Significant toxicities attributable to TBI were rare. One patient had acute lung injury and another had pericardial effusion. There were 3 transplant related mortalities and 7 had disease relapse.
Conclusion: TBI based conditioning regimen is safe and a feasible option in centers with equipment and technical expertise. Outcomes of patients primarily depend upon underlying disease biology.
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