A study on haematological abnormalities in chronic liver disease
Abstract
The liver is the largest organ in the body and one of the most complex functioning organs with a wide array of functions. It plays a major role in carbohydrate, protein, lipid metabolism; inactivation of various toxins, metabolism of drugs, hormones, synthesis of plasma proteins & maintenance of immunity (Kupffer cells). Right from being a primary site of haematopoiesis in fetal life to maintenance of hematological parameters in postnatal life; the liver has an extremely important role in maintenance of blood homeostasis. It acts as a storage depot for Iron, Folic acid & Vitamin B12, secretes clotting factors and inhibitors. Hence it’s not surprising to see a wide range of hematological abnormalities in liver diseases.In chronic liver disease the presence of jaundice, liver cell failure, portal hypertension and hypersplenism, reduced red cell half-life all influence peripheral blood picture. Both Liver cell failure & cholestasis can derange the coagulation system. Dietary deficiencies, bleeding, alcoholism and abnormalities in hepatic synthesis of proteins used for blood formation or coagulation add to the problem liver disease. This study was undertaken to describe the hematological abnormalities in decompensated chronic liver disease so that measures could be taken to correct them and reduce morbidity.
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