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Congenitally Corrected Transposition of Great Arteries is a rare cardiac malformation characterized by the combination of discordant atrioventricular or ventriculoarterial connections, usually accompanied by other cardiovascular malformations. Incidence has been reported to be around 133,000 live births, accounting for approximately 0.05 of  congenital heart malformations. Associated malformations may include inter ventricular communications, dextrocardia, obstruction of the outlet from the morphologically left ventricle and tricuspid valve abnormalities. The clinical picture and age of onset depends on the associated malformations. Bradycardia, single loud S1 and a heart murmur are the most common manifestations. In the rare cases where there are no associated malformations, congenitally corrected TGA can lead to progressive AV valve regurgitation and failure of the systemic ventricle. The diagnosis can also be made late in life when the patient presents with complete heart block or  cardiac failure. Etiology is currently unknown and with  increase in incidence among families with previous cases of CCTGA reported. Diagnosis can be made by fetal  echocardiography, but is far more commonly made postnatally with clinical signs and echocardiography. Prognosis is defined by the associated malformations and on the timing and approach to palliative surgical care. This case is presented for its rarity and the age at presentation, this patient being one of the eldest reported.


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Carey, L.S. &Ruttenberg, H.D. (1964). Roentgenographic features of congenital corrected transposition of the great vessels: A comparative study of 33 cases with a roentgenographic classification based on the associated malformations and hemodynamic states. American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine, Vol. 92, No. 3, (September 1964), pp. 623- 651, ISSN 0002-9580.

Daliento, L., Corrado, D., Buja, G., John, N., Nava, A., &Thiene, G. (1986). Rhythm and Conduction Disturbances in Isolated, Congenitally Corrected Transposition of the Great Arteries.The American Journal of Cardiology, Vol. 58, No. 3, (August 1986), pp. 314-318, ISSN 0002-9149.

Dore, A., Houde, C., Chan, K-L., Ducharme, A., Khairy, P., Juneau, M., Marcotte, F., & Mercier, LA. (2005). Angiotensin Receptor Blockade and Exercise Capacity in Adults with Systemic Right Ventricles: A Multicenter, Randomized, Placebo- Controlled Clinical Trial.Circulation, Vol. 112, No. 16, (October 2005), pp. 2411-2416, ISSN 1524-4539.

Graham, T.P. & Markham, L.W. (2010). Congenitally corrected transposition of the great arteries, In: Diagnosis and Management of Adult Congenital Heart Disease, M.D. Gatzoulis& G.D. Webb (Eds.), pp. 371-377, Churchill Livingstone, ISBN 978-0-7020-3 426-8, Edinburgh.

Graham, T.P., Markham, L., Parra, D.P., &Bichell, D. (2007). Congenitally Corrected Transposition of the Great Arteries: An Update. Current Treatment Options in Cardiovascular Medicine, Vol. 9, No. 5, (October 2007), pp. 405-413, ISBN 1092-8464.

Hornung, T.S. & Calder, L. (2010). Congenitally corrected transposition of the great arteries. Heart , Vol. 96, No. 14, (July 2010), pp. 1154-1161, ISSN 1468-201X..

Orchard, E.A., Ormerod, O., Myerson, S., &Westaby, S. (2010). Congenitally Corrected Transposition of the Great Arteries Presenting in a Nonagenarian.Circulation, Vol.122, No. 9, (August

, pp. e441-444, ISSN 1524-4539.

Piacentini, G., Digilio M.C., Capolino, R., De Zorzi, A., Toscano, A., Sarkozy, A., D’Agostino,R., Marasini, M., Russo, M.G., Dallapiccola, B., & Marino, B. (2005). Familial Recurrence of Heart Defects in Subjects with Congenitally Corrected Transposition of the Great Arteries. American Journal of Medical Genetics, Vol. 137, No. 2, (August 2005), pp. 176-180, ISSN 1552-4833.

Scardi, S., Knoll, P., &Pandullo, C. (1999). Corrected Transposition of the Great Vessels and SitusInversus Viscerumin a 65-Year-Old Oligosymptomatic Woman. Circulation, Vol. 100, No. 7, (August 1999), pp. 777, ISSN 1 524-4539.

Van Praagh, R., Papagiannis, J., Grunenfelder, J., Bartram, U., &Martanovic, P. (1998) Pathologic anatomy of corrected transposition of the great arteries and surgical implications. American Heart Journal, Vol 135, No. 5, (May 1998), pp. 772-785, ISSN 0002-8703.

Warnes, C.A. (2006). Transposition of the Great Arteries. Circulation, Vol. 114, No. 24, (December 2006), pp. 2699-2709, ISSN 1524-4539.


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