A RANDOMISED STUDY TO COMPARE INTUBATING CONDITIONS OF ROCURONIUM BROMIDE WITH PRIMING AND WITHOUT PRIMING
Abstract
Introduction Rocuronium produces faster neuromuscular blockade compared with other neuromuscular blocking drugs. It produces comparable intubating conditions to that of succinylcholine, but does not have the short intubation time of the latter. Hence, it may not be preferable for rapid sequence intubation, but rocuronium with priming may produce comparable intubating time and conditions to that of succinylcholine. Rocuronium with priming may be an alternative to succinylcholine in rapid sequence intubation in conditions where succinylcholine is contraindicated. The present study was conducted to compare the intubating conditions and intubation time of rocuronium with and without priming. Methods This is a randomised prospective double blind study in which sixty patients of ASA physical status I and II, aged between 18 and 60 years, of both sexes, were randomly divided into priming and control groups of 30 each. Patients in the priming group received 0.06 mgkg of rocuronium and those in the control group received normal saline. All patients received fentanyl 2 micskg, followed by thiopentone 5 mgkg for induction. Intubating dose of rocuronium 0.54 mgkg in the priming group and 0.6 mgkg in the control group were administered 3 minutes .In both the groups all the anaesthetic drugs were given by seperate coanaesthesiologist. Onset time of intubation was assessed using a Train of Four stimuli, and the intubating conditions were compared by the Cooper scoring system by a another separate anaesthesiologist. Results The onset time of intubation was 52.607.40 s in the priming group and 93.0010.60 s in the control group, with excellent intubating conditions in both the groups and without any adverse effects. onclusion Priming with rocuronium provides excellent intubating conditions in less than 60 s with no adverse effects.
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