RASMUSSEN ENCEPHALITIS - A CASE REPORT
Abstract
Rasmussen Encephalitis is a rare, immune
mediated disease characterized by
refractory seizures, progressive neurological
dysfunction and unilateral hemispheric
atrophy. This disorder typically
involves a single cerebral hemisphere,
affecting mainly children and adolescents.
We report a case of Rasmussen
Encephalitis in a young girl who was admitted
with complaints of recurrent focal
motor seizures involving right upper and
lower limbs for the past 5 years. There
was a progressive increase in the seizure
frequency and severity despite adequate
drug compliance. Patient also developed
progressive decline in the cognitive
functions and speech disturbances
with weakness of right upper and lower
limbs for the past 2 years. Initial CT Brain
done was normal. Periodic CT Brain imaging
showed progressive atrophy of the
entire left cerebral hemisphere.
Full Text:
PDFReferences
(1) Andermann E, Oguni H, Guttmann
RD, Osterland CK, Antel JP,
Eeg-Olofsson O, et al. Genetic aspects
of chronic encephalitis. In: Andermann
F, editor. Chronic encephalitis
and epilepsy. Boston: Butterworth-
Heinemann; 1991. p. 167–75.
(2) Bien, CG; Granata, Antozzi
(2005). "Pathogenesis, diagnosis
and treatment of Rasmussen encephalitis:
a European consensus
statement". Brain 128 (Pt 3): 454–
(3) Granata T, Gobbi G, Spreafico R,
Vigevano F, Capovilla G, Ragona F,
et al. Rasmussen’s encephalitis:
early characteristics allow diagnosis.
Neurology 2003b; 60: 422–5.
(4) Grenier Y, Antel JP, Osterland
CK. Immunologic studies in
chronic encephalitis of Rasmussen.
In: Andermann F, editor. Chronic encephalitis
and epilepsy. Rasmussen’s
syndrome. Boston: Butterworth
-Heinemann; 1991.p. 125–34.
(5) Hart, YM; Cortez, Andermann,
Hwang, Fish (1994). "Medical treatment
of Rasmussen syndrome
(chronic encephalitis and epilepsy):
effect of high-dose steroids or immunoglobulins
in 19 patients". Neurology
(6): 1030–1036.
(6) Rasmussen T, Olszewski J, Lloyd
-Smith D (1958). "Focal seizures due
to chronic localized encephalitis".
Neurology 8 (6): 435–45.
(7) Rogers SW, Andrews PI, Gahring
LC et al. (1994). "Autoantibodies to
glutamate receptor GluR3 in Rasmussen's
encephalitis". Science 265
(5172): 648–51.
(8) Takahashi Y, Mori H, Mishina M et
al. (2005). "Autoantibodies and cellmediated
autoimmunity to NMDA-type
GluRepsilon2 in patients with Rasmussen's
encephalitis and chronic progressive
epilepsia partialis continua".
Epilepsia 46 (Suppl 5): 152–158
Watson R, Jiang Y, Bermudez I et al.
(2004). "Absence of antibodies to glutamate
receptor type 3 (GluR3) in Rasmussen
encephalitis". Neurology 63
(1): 43–50.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An initiative of The Tamil Nadu Dr M.G.R. Medical University