EVALUATION OF OXIDATIVE STRESS AND SERUM LIPID PROFILE IN PREECLAMPSIA
Abstract
Preeclampsia is a multisystem disorder that adversely affects the mother and the fetus.
According to the current knowledge, dyslipidemia and oxidative stress are the major contributing
factors to the pathogenesis of preeclampsia. Oxidative stress increases during preeclampsia which
enhances free radical mediated lipid peroxidation and endothelial dysfunction. The aim of the present
study was to estimate the plasma levels of Malondialdehyde, a lipid peroxidation product and to
correlate it with the serum lipid profile alterations in preeclamptic women. METHODS 50 women with
preeclampsia and 50 normal pregnant women who were matched for maternal and gestational age
were selected for the study. Fasting venous samples were collected and plasma Malondialdehyde
(MDA), serum total cholesterol (TC), triglycerides (TGL), high density lipoprotein (HDL), low density
lipoprotein (LDL) and very low density lipoprotein (VLDL) were estimated. Plasma Malondialdehyde
was estimated by spectrophotometric method. RESULTS MDA, TC, TGL, LDL and VLDL levels were
significantly elevated (p0.001) and HDL level was significantly reduced (p0.001) in preeclamptic
patients when compared to the control group. MDA was found to have a significant positive
correlation with TC, TGL, LDL and VLDL (p0.01) and a significant negative correlation with HDL
(p0.01) in preeclamptic cases. CONCLUSION The present study indicates that dyslipidemia leads to
excessive lipid peroxidation which in turn results in increased oxidative stress in preeclampsia. The
resultant endothelial dysfunction may contribute to the increased risk of future cardiovascular disease
in preeclamptic women.
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Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY. Pregnancy
Hypertension. In: Alyssa Fried and Karen Davis, editors. Williams Obstetrics. 23rd edition. NewYork:
McGraw Hill companies; 2010. p.706-709
David A.Miller. Hypertension in pregnancy. In: Annie M.Sydor & Karen Edmonson, editors.
Current diagnosis and treatment Obstetrics and Gynaecology. 10th edition. NewYork: McGraw Hill
companies; 2007. p.320
Krishna Menon MK and Palaniappan B. Hypertensive disorders in pregnancy. In: Sarala
Gopalan and Vanita Jain, editors. Mudhaliar and Menon’s Clinical Obstetrics. 11th edition.
Hyderabad: University Press; 2011. p.133-154
Dutta DC. Hypertensive disorders in pregnancy. In: Hiralal Konar, editor. Textbook of
Obstetrics. 7th edition. Kolkata: New central book agency; 2011. p.223
William M Barron. Hypertension. In: William M Barron and Lindheimer MD, editors. Medical
disorders during pregnancy. 3rd edition. Missouri: Mosby; 2000. p.310
Ullas Kamath, Guruprasad Rao, Shobha U Kamath, Lavanya Rai. Maternal and fetal indicators
of oxidative stress during pregnancy-induced hypertension (PIH). International Journal of Applied
Biology and Pharmaceutical Technology. Jan-Mar-2011; Volume 2 (1):405-409
Mohanty S, Sahu PK, Mandal MK, Mohapatra PC, Panda A. Evaluation of oxidative stress in
pregnancy induced hypertension. Indian Journal of Clinical Biochemistry. 2006; 21(1):101-105
Wickens D, Wilkins MH, Lunec J, Ball G and Dormandy TL. Free radical oxidation (peroxidation)
products in plasma in normal and abnormal pregnancy, Ann. Clin. Biochem.1981; 18:158-162
Krishna Mohan S and Venkataramana G. Status of lipid peroxidation, glutathione, ascorbic acid,
vitamin E, and antioxidant enzymes in patients with pregnancy-induced hypertension. Indian J Physiol
Pharmacol. 2007; 51 (3):284-288
Zhou JF, Wang XY, Shangguan XJ. Increased oxidative stress in women with pregnancy-induced
hypertension. Biomed Environ Sci. 2005; Dec;18(6):419-426
Andrew Shennan. Hypertensive disorders. In: D.Keith Edmonds, editor. Dewhurst’s Textbook of
Obstetrics and Gynaecology. 7th edition. Massachusetts: Blackwell publishing, Oxford University
press; 2007. p.228
Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on Malondialdehyde as toxic
molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 2005 Aug; 15(4):316-
Kashinakunti SV, Sunitha H, Gurupadappa K, Shankarprasad DS, Suryaprakash G and Ingin JB.
Lipid peroxidation and antioxidant status in preeclampsia. Al Ameen J Med Sci. 2010; 3(1):38-41
Suchanda Sahu, Rebecca Abraham, Vedavalli R and Mary Daniel. Study of lipid profile, lipid
peroxidation and vitamin E in pregnancy induced hypertension. Indian J Physiol Pharmacol. 2009;
(4):365-369
Ekambaram Padmini, Munuswamy Usha Rani. Lipid profile alterations and oxidative stress in
patients with preeclampsia: role of black tea extract on disease management. Turk J Med Sci. 2011;
(5):761-768
Usha Adiga, Vivian D ‘souza, Asha Kamath, Nandini Mangalore. Antioxidant activity and lipid
peroxidation in preeclampsia. J Chin Med Assoc. October 2007; Vol 70, No.10
Lakshmiprabha S, Mohanty B, Mohanty PK, Diwakar A, Anil Kumar D, Acharya V et al. A study of
serum lipid profile and oxidative stress marker in healthy pregnancy and in preeclampsia.
International Journal of Current Research. June 2011; Vol.3, Issue 6:160-162
Carl A.Hubel. Oxidative stress in the pathogenesis of preeclampsia. P.S.E.B.M. 1999; Vol.
:222-231
Maarten T.M. Raijmakers, Ralf Dechend, Lucilla Poston. Oxidative stress and preeclampsia,
Rationale for antioxidant clinical trials. Hypertension. 2004;44:374-380
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