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A RARE CASE OF KLEINE-LEVIN SYNDROME

NAGARAJAN S SUBRAMANI

Abstract


Kleine-Levin syndrome (KLS) is known for more than a century, with defined clinical
features, but no clear cause or treatment. Diagnosis is exclusively clinical and no systematic studies
on treatment available. Lithium has some promises in treating KLS and it is a benign self limiting
syndrome. Here we present a case of Kleine-Levin syndrome who was diagnosed initially as atypical
depression and treated later with Lithium.


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References


American Academy of Sleep Medicine. The International Classification of Sleep

Disorders—Revised Diagnostic and Coding Manual. Chicago, IL: American Academy of Sleep

Medicine; 2005. p.

Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Arnulf I, Zeitzer JM,

File J, Farber N, Mignot E. Brain. 2005 Dec;128(Pt 12):2763-76. Epub 2005 Oct 17.

Clinical and polysomnographic characteristics of 34 patients with Kleine-Levin syndrome.

Gadoth N, Kesler A, Vainstein G, Peled R, Lavie P. J Sleep Res. 2001 Dec;10(4):337-41.

A case report of Kleine-Levin syndrome in an adolescent girl. Janicki S, Franco K, Zarko R.

Psychosomatics. 2001 Jul-Aug;42(4):350-2.

SPECT findings in the Kleine-Levin syndrome. Huang YS, Guilleminault C, Kao PF, Liu FY.

Sleep. 2005 Aug 1;28(8):955-60.

Kleine-Levin syndrome following acute viral encephalitis. Merriam AE. Biol Psychiatry. 1986

Nov;21(13):1301-4.

Interepisodic morbidity in Kleine-Levin syndrome. Sagar RS, Khandelwal SK, Gupta S. Br J

Psychiatry. 1990 Jul;157:139-41.

The treatment of Kleine-Levin syndrome with lithium. Goldberg MA Can J Psychiatry. 1983

Oct; 28(6):491-3.

Kleine-Levin syndrome (recurrent hypersomnia of male adolescents. Fresco R, Giudicelli S,

Poinso Y, Tatossian A, Mouren P. Ann Med Psychol (Paris). 1971 May;1(5):625-68.

Photosensitivity during the hypersomnic phase in a patient with Kleine-Levin syndrome.

Papacostas SS. J Child Neurol. 2003 Jun;18(6):432-3.

Pharmacological treatment for Kleine-Levin Syndrome. Oliveira MM, Conti C, Saconato H,

Fernandes do Prado G. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD006685. doi:

1002/14651858.CD006685.pub2.

The psychiatric symptomatology in Kleine-Levin syndrome. Mukaddes NM, Alyanak B, Kora

ME, Polvan O Child Psychiatry Hum Dev. 1999 Spring; 29(3):253-8.

Episodic diencephalic hypoperfusion in Kleine-Levin syndrome. Hong SB, Joo EY, Tae WS,

Lee J, Han SJ, Lee HW Sleep. 2006 Aug; 29(8):1091-3.

Polysomnography in Kleine-Levin syndrome. Huang YS, Lin YH, Guilleminault C. Neurology.

Mar 4;70(10):795-801. doi: 10.1212/01.wnl.0000304133.00875.2b.

Kleine–Levin syndrome: Etiology, diagnosis, and treatment Santosh Ramdurg, Ann Indian

Acad Neurol. 2010 Oct-Dec; 13(4): 241–246. doi: 10.4103/0972-2327.74185

Kleine-Levin syndrome ethiopathogenesis and treatment. Smolík P, Roth B. Acta Univ Carol

Med Monogr. 1988;128:5-94.


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