RARE PRESENTATION OF RARE VARIANT OF GUILLAIN BARRE SYNDROME
Abstract
Guillain-Barre syndrome (GBS) may be described as a collection of clinical syndromes
that manifests as an acute inflammatory polyradiculoneuropathy with resultant weakness and
diminished reflexes. There have been several descriptions of reflex preservation and hyperreflexia in
the acute motor axonal neuropathy (AMAN) variant of GBS in Chinese, Japanese and European
populations but it is not common in the Indian subcontinent.1,2 We present one such case of AMAN
who presented with acute onset of ascending weakness with rapid progression to respiratory failure,
retained reflexes and extensor plantar. Diagnosis was confirmed with CSF analysis and nerve
conduction studies and child was treated with intravenous immunoglobulin for 5 days and discharged
after significant improvement .This case report is to impress upon treating pediatricians and
neurologists in recognising the rare presentations of this rare variant.
Full Text:
PDFReferences
Kuwabara S, Ogawara K, Koga M, Mori M, Hattoori T, Yuki N - Hyperreflexia in Guillain-Barre
syndrome : Relationship with Acute Motor Axonal Neuropathy and anti-GM1 antibody. J Neurol
Neurosurg Psychiatry 1999;67:180-4.
McKhann GM, Cornblath DR, Griffith JW, Ho TW, Li CY, Jiang Z, et al - Acute Motor Axonal
Neuropathy: A frequent cause of acute flaccid paralysis in China. Ann Neurol 1993;33:333-42
Jacobs BC, van Doorn PA, Schmitz PI, Tio-Gillen AP, Herbrink P, Visser LH, et al -
Campylobacter jejuni infections and anti-GM1 antibodies in Guillain-Barré syndrome. Ann Neurol.
Aug 1996;40(2):181-7. [Medline].
Koga M, Takahashi M, Masuda M, Hirata K, Yuki N - Campylobacter gene polymorphism as a
determinant of clinical features of Guillain-Barré syndrome. Neurology. Nov 8 2005;65(9):1376-81. [
Medline].
Kimoto K, Koga M, Odaka M, Hirata K, Takahashi M, Li J, et al - Relationship of bacterial strains
to clinical syndromes of Campylobacter-associated neuropathies. Neurology. Nov 28
;67(10):1837-43. [Medline].
Geleijns K, Roos A, Houwing-Duistermaat JJ, van Rijs W, Tio-Gillen AP, Laman JD, et al -
Mannosebinding lectin contributes to the severity of Guillain-Barré syndrome - J Immunol. Sep 15
;177(6):4211-7. [Medline].
Ropper AH, Wijdicks EFM, Truax BT - Guillain-Barré syndrome, FA Davis, Philadelphia 1991.
p.57
Asbury AK, Cornblath DR - Assessment of current diagnostic criteria for Guillain-Barré
syndrome. Ann Neurol. 1990;27 Suppl:S21-4. [Medline].
Ho TW, Li CY, Cornblath DR, et al - Patterns of recovery in the Guillain-Barre syndromes.
Neurology 1997;48:695.
Brown WF, Feasby TE, Hahn AF - Electrophysiological changes in the acute "axonal" form of
Guillain-Barre syndrome. Muscle Nerve. Feb 1993;16(2):200-5. [Medline].
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An initiative of The Tamil Nadu Dr M.G.R. Medical University