SIGNIFICANCE OF OVERALL TREATMENT TIME IN THE CONTEXT OF CHEMORADIATION AND BRACHYTHERAPY IN CARCINOMA CERVIX
Abstract
Retrospective evaluation of the previously treated carcinoma cervix
patients for the significance of overall treatment time in Carcinoma cervix patients AIM To look at the
effect of overall treatment time and outcome of Carcinoma cervix patients in the context of
Chemotherapy and Brachytherapy. MATERIALS AND METHODS Details of hundred and two
patients with carcinoma cervix(all stages) treated in the past fifteen years in our institute was
collected and analyzed for the outcome and factors that can contribute to it RESULTS Out of the 102
patients, 66 patients(64.7) received concurrent chemotherapy and 36 did not(35.3), 70 patients(68.6)
received brachytherapy where as 32 patients (31.4) did not. Among the patients who had
chemoirradiation 49 underwent brachytherapy. 79 patients(77.5) were disease free at the time of last
follow up and 23 patients(22.5) had recurrent or progressive disease. In the patients who had
chemoirradiation followed by brachytherapy, the mean duration of completion of external radiation
therapy was 46.89 days (SD 11.504) and the mean duration of overall treatment (including
brachytherapy) was 61.05 days (SD 12.89). Mean duration of treatment within 60 days with or without
brachytherapy had significance in the outcome of treatment (p value 0.004 for concurrent
chemoirradiation followed by brachytherapy). CONCLUSIONS Overall treatment time in carcinoma
cervix patients is an important factor which can influence the outcome.
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