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Thrombotic microangiopathy induced by oral contraceptive pills - a case report.

MURUGESAN V

Abstract


Thrombotic microangiopathy(TMA) is a condition characterized by changes in endothelial
phenotype. Here the characterized lesion is the arteriolar and capillary wall thickening, intra vascular
platelet fibrin thrombi and partial or complete vessel lumen occlusion. It is caused by complement
abnormalities, ADAMTS 13 deficiency, infections, pregnancy, drugs or metastatic carcinomas. Drugs
like quinine are proved causative factors for thrombotic microangiopathies1 and included as etiologic
factors in classification of TMAs. There are anecdotal reports of oral contraceptive pills causing
thrombotic microangiopathies. Here we describe a 37 year old female presenting with thrombotic
microangiopathy caused by oral contraceptive pills. She was successfully treated with plasmaphresis.

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