THREE CASES OF EPISODIC ATAXIA, HEMIPLEGIC MIGRAINE SPINOCEREBELLAR ATAXIA WITHIN A SINGLE FAMILY
Abstract
presenting with features of familial hemiplegic migraine type 1 and episodic ataxia type 2. Her
younger sibling who was 12 years old presented with features of ataxia. Her 42 year old father had
features suggestive of spinocerebellar ataxia type 6.The first child had headache which was throbbing
and pulsatile associated with giddiness ,ataxia,nystagmus with left sided hemiplegia which was
episodic and each episode lasting for 4 hours for the past 2 years and the patient gradually recovered
from hemiplegia within 12 hrs with treatment . The second patient presented with ataxia with tandem
gait difficulty which was persistent not positional and paroxysmal for 2 years. The third patient had
insidious onset and progressive nature of unsteadiness ,dysarthria ,appendicular incoordination and
intention tremor of six years duration . These three members of the same family with familial
hemiplegic migraine type1 , episodic ataxia type 2 and spinocerebellar ataxia type 6 could be due to a
single chromosomal disorder presenting with a channellopathy.
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