A CASE REPORT - AUTOIMMUNE ENCEPHALITIS MIMICING VIRAL ENCEPHALITIS
Abstract
marriage, full term, with normal developmental milestones upto the age of 8 months who developed
fever with seizures treated outside our hospital as CNS infection, hypoxic sequale, presented to our
hospital with refractory seizures and abnormal chorea athetoid movements with worsening of
milestones. On reevaluation diagnosed as anti-NMDA receptor antibody positive encephalitis and
treated with steroids and intravenous immunoglobulin (Iv Ig) showed improvement even after 2
months of illness.
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Gable MS, Gavali S, Radner A, et al. Anti-NMDA receptor encephalitis: report Of ten cases and
comparison with viral encephalitis. Eur J Clin Microbiol Infect Dis 2009; 28:1421–1429.
Granerod J, Ambrose HE, Davies NW, et al. Causes of encephalitis and differences in their
clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect
Dis 2010; 10:835–844.
Gable MS, Sheriff H, Dalmau J, et al. The frequency of autoimmune N-methyl-D-aspartate
receptor encephalitis surpasses that of individual viral etiologies In young individuals enrolled in
the California Encephalitis Project. Clin Infect Dis 2012; 54:899–904.
Armangue T, Leypoldt F, Malaga I, et al. Herpes simplex virus encephalitis is a trigger of brain
autoimmunity. Ann Neurol 2014; 75:317–323. Study showing that HSE can trigger synaptic
autoimmunity, leading to the syndrome choreoathetosis post-HSE.
Thomas L, Mailles A, Desestret V, et al. Autoimmune N-methyl-D-aspartate receptor encephalitis
is a differential diagnosis of infectious encephalitis. J Infect 2013. [Epub ahead of print]
Lai M, Hughes EG, Peng X, et al. AMPA receptor antibodies in limbic encephalitis alter synaptic
receptor location. Ann Neurol 2009; 65:424–434.
Lancaster E, Martinez-Hernandez E, et al. Antibodies to metabotropic glutamate receptor 5 in the
Ophelia syndrome. Neurology 2011; 77:1698–1701.
Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term
outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet
Neurol 2013; 12:157–165.
Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and
analysis of the effects of antibodies. Lancet Neurol 2008; 7:1091–1098.
Florance NR, Davis RL, Lam C, et al. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis
in children and adolescents. Ann Neurol 2009; 66:11–18.
Armangue T, Titulaer MJ, Malaga I, et al. Pediatric anti-N-methyl-D-aspartate receptor
encephalitis: clinical analysis and novel findings in a series of 20 patients. J Pediatr 2013;
:850–856.
Viaccoz A, Desestret V, Ducray F, et al. Clinical specificities of adult male patients with NMDA
receptor antibodies encephalitis. Neurology 2014; 82:556–563.
Titulaer MJ, Dalmau J. Seizures as first symptom of anti-NMDA receptor encephalitis are more
common in men. Neurology 2014; 82:550–551.
Leypoldt F, Titulaer MJ, Aguilar E, et al. Herpes simplex virus-1 encephalitis can trigger anti-
NMDA receptor encephalitis: a case report. Neurology 2013; 81:1637–1639.
Mohammad SS, Sinclair K, Pillai S, et al. Herpes simplex encephalitis relapse with chorea is
associated with autoantibodies to N-methyl-D-aspartate receptor or dopamine-2 receptor. Mov
Disord 2013; 29:117–122.
Hargrave DR, Webb DW. Movement disorders in association with herpes simplex virus
encephalitis in children: a review. Dev Med Child Neurol 1998; 40:640–642.
Titulaer MJ, Leypoldt F, Dalmau J. Antibodies to N-methyl-D-aspartate and other synaptic
receptors in choreoathetosis and relapsing symptoms postherpes virus encephalitis. Mov Disord
; 29:3–6.
De Tie`ge X, Rozenberg F, Des Portes V, et al. Herpes simplex encephalitis relapses in children:
differentiation of two neurologic entities. Neurology 2003; 61:241–243.
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