NEUROENDOCRINE TUMORS IN DECOMPENSATED LIVER DISEASE
Abstract
We report two cases of neuroendocrine
tumors in patients with decompensated
chronic liver disease. Neuroendocrine
tumour in the setting of decompensated
liver disease is a very rare entity thus the
presentation. Patients who had decompensated
chronic liver disease, diagnosed
by clinical, laboratory and imaging
criteria underwent upper gastrointestinal
endoscopy. During endoscopy, polyps
numbering one to numerous were found
in the stomach and duodenum. Biopsy
was taken from polyps and sent for histopathological
examination. Histopathological
examination was suggestive of neuroendocrine
tumor. To confirm the diagnosis,
Immunohistochemistry for neuroendocrine
markers, chromogranin A,
synaptophysin, Leu7, and neuronspecific
enolase was done. After confirmation
with positive immunohistochemistry, metastatic
work-up was done using CECT
abdomen and PET CT scan
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PDFReferences
Eltawil KM, Gustafsson BI, Kidd M, Modlin
IM Neuroendocrine tumors of the gallbladder
an evaluation and reassessment of
management strategy. J Clin Gastroenterol
, 44687-695.
Zuetenhorst JM, Taal BG Metastatic carcinoid
tumors a clinical review. Oncologist
, 10123-131.
National Cancer Institute. Surveillance,
Epidemiology, and End Results (SEER) Stat
Fact Sheets.
httpseer.cancer.govcsr1975_2004results_m
ergedtopic_prevalence.pdf. Accessed January
, 2012.
Taal BG, Visser O. Epidemiology of neuroendocrine
tumours Department of Gastroenterology,
Netherlands Cancer Institute,
Antoni van Leeuwenhoek Hospital, Amsterdam,
The NetherlandsNeuroendocrinology.
Lin IM, Lye KD, Kidd M A 5-
decade analysis of 13,715 carcinoid tumors.
Cancer 2003, 97 Mod934-959.
Modlin IM, Lye K, Kidd M Carcinoid tumors.
In Endocrine Surgery. Edited by
Schwartz AE, Pertsemlidis D, Gagner M.
New York Marcel Dekker, Inc 2003611-639.
Capella C, Heitz PU, Hofler H, Solcia E,
Kloppel G Revised classification of neuroendocrinetumours
of the lung, pancreas and
gut. Virchows Arch 1995, 425547-560.
Memon MA, Nelson H. Gastrointestinal
carcinoid tumors current management
strategies. Dis Colon Rectum
401101-18.
Modlin IM, Sandor A. An analysis of
cases of carcinoid tumors. Cancer
79813-29.
Dhall D, Mertens R, et al.Ki-67 proliferative
index predicts progressionfree
survival of patients with welldifferentiated
ileal neuroendocrine tumors.
Hum Pathol. 2012 Apr43(4)489-
Aggarwal G, Obideen K, Wehbi M
Carcinoid tumors what should increase
our suspicion Cleve Clin J Med. 2008
Dec75(12)849-55
Garrison RN, Cryer HM, Howard
DA, et al. Clarification of risk factors for
abdominal operations in patients with
hepatic cirrhosis. Ann Surg
Mansour A, Watson W, Shayani V,
et al. Abdominal operations in patients
with cirrhosis still a major surgical challenge.
Surgery 19971227305
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