CASE REPORT ON CHRONIC CYCLOSPORINE TOXICITY IN A CARDIAC TRANSPLANT RECIPIENT
Abstract
Calcineurin inhibitors (CNI) have revolutionized
transplantation of non renal organs
including heart, liver, lung, and pancreas.
We report cyclosporine-induced
renal failure in a 61year old man who underwent
deceased donor orthotopic heart
transplantation in April 2010. He was
started on triple immuno-suppression including
cyclosporine, mycophenolate
mofetil (MMF) and steroids. Fourteen
months later he had developed renal failure
which was proved to be due to
chronic cyclosporine nephrotoxicity. We
discuss the pathophysiological mechanisms
of cyclosporine toxicity in cardiac
transplant recipients and measures to
reduce the toxicity.
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